Born in Weimar in 1966, Wolfram Große took clarinet lessons from the age of ten. In 1980 he became a pupil at the Spezialschule für Musik in Berlin before going on to study from 1984 to 1988 under Ewald Koch at the Hanns Eisler College of Music, also in Berlin.

Wolfram Große’s career as an orchestral musician began in 1988 when he was became deputy principal clarinet of the Berlin Symphony Orchestra. From 1989 to 1999 he was principal clarinet at Frankfurt Opera.

In 1999 he joined the Staatskapelle Dresden in the same position. Since 2000 Wolfram Große has also been principal clarinet of the Bayreuth Festival Orchestra. In addition to his orchestra duties he is a member of the Wind Quintet of the Staatskapelle Dresden.

As a chamber musician and soloist Wolfram Große has won prizes at several competitions, for example in Munich, Markneukirchen and Colmar. In 2002 he was awarded the Fritz Busch Prize by the Semperoper Foundation.