Born in Palermo, Gaetano d’Espinosa finished his extensive education including violin (with Mihai Spinei and Salvatore Accardo), piano, composition (with Turi Belfiore) and philosophy in Italy. He began his career as a violinist with the Orchestra da Camera Italiana and the Mahler Chamber Orchestra, followed by an engagement with the Sächsische Staatskapelle Dresden from 2001 to 2008, as Assistant First Concertmaster from 2003 onward. During this period of time he developed his passion for conducting and was able to assist Fabio Luisi – his mentor at the time – with different productions. He left the orchestra in 2008 to fully committ to conducting: His most important debuts include Verdis »La traviata« at the Sächsische Staatsoper Dresden in 2010. 2012 he was appointed Principal Guest Conductor at the Orchestra Sinfonica di Milano »Giuseppe Verdi«. He conducted performances of Leoncavallos »Pagliacci« and Verdis »La traviata« at the Teatro Carlo Felice in Genoa in 2011 and 2013. At the Oper Graz he conducted Verdis »Otello« in 2011, followed by Donizettis »Maria Stuarda« in 2012. Also, in 2012 he conducted Puccinis »Il Trittico« at the Opera de Lyon. He holds a connections with the Teatro La Fenice in Venice since 2011, both in symphonic and opera repertoire, including performances of »La traviata« and Bellinis »Norma«.
He also regularly works together with the Orchestra della RAI di Torino for concerts and recordings. 2012 he was invited by the Orchestra dell‘Accademia Nazionale di Santa Cecilia in Rome and 2014 for Symphony concerts. He appears regularly with Japanese orchestras such as the NHK Orchestra in Tokyo, the Japan Century Orchestra in Osaka, the Tokyo Metropolitan Orchestra, the Osaka Philharmonic, the Gunma Symphony Orchestra, the Hyogo PAC Orchestra and the PMF Festival Orchestra in Sapporo. He also works with orchestras such as the Orchestra del Maggio Musicale Fiorentino, the Orchestre de Chambre de Lausanne, the Orchestre de la Suisse Romande, the Orchestre de l'Ile de France, the Bamberger Symphoniker, the Orchestre National de Belgique, the Prager Philharmoniker and the Kremerata Baltica.