Born into a family of musicians in Munich, her career began at an early age. Her breakthrough came at the latest with numerous prizes at the Sarasate, Paganini and Tchaikovsky competitions, which quickly took her to the world's most important stages as a soloist. As a soloist and chamber musician, Yuki Manuela Janke also inspires as concertmaster of the most traditional orchestras. Her interpretation of Richard Strauss' "Heldenleben" in the Golden Hall in Vienna with the Staatskapelle Dresden and Christian Thielemann attracted particular attention.
As concertmaster of the Staatskapelle Berlin, she enjoys the trust of conductors such as Daniel Barenboim and Zubin Mehta. She is a regular guest with the Munich Philharmonic Orchestra, the Leipzig Gewandhaus

Orchestra and various orchestras abroad. She received her most important musical impulses from Igor Ozim at the Mozarteum Salzburg and through chamber music collaborations with Christoph Eschenbach, Wolfgang Emanuel Schmidt, the Hagen Quartet and the Tokyo String Quartet. Her broad repertoire ranges from baroque and romantic music to contemporary composers such as Jörg Widmann, Wolfgang Rihm, Krzysztof Meyer, Nicolas Bacri and Markus Schmitt. Her repertoire also includes forgotten works such as Franz Clement's Violin Concerto, which Janke recorded with Reinhard Goebel and the Nuremberg Symphony Orchestra. She plays on a violin by Robert König & Michael Betcher.